Pragmatic vs Explanatory Trials

Pragmatic vs Explanatory Trials

Randomized Control Trials vs Pragmatic Clinical Trials

Randomized Control Trials vs Pragmatic Clinical Trials

Pragmatic Clinical Trials

“Does the intervention work in real life?”
 

Designed to evaluate the effectiveness of interventions in real-life routine practice conditions.

  • Test interventions in every day clinical settings to maximize generalizability.
  • Designed to improve practice and policy.
  • Most trials have some elements of both explanatory and pragmatic design.
  • May be used to assess for effectiveness once safety & efficacy is established.

Limitations include:

  • Cost, may require more complex study design.
  • Difficult to blind participants and clinicians although assessors can often be blinded.